Uji Efektivitas Serum Anti Jerawat Dari Ekstrak Kulit Pepaya (Carica papaya L.) Terhadap Pertumbuhan Bakteri Cutibacterium acnes Dan Staphylococcus epidermidis
DOI:
https://doi.org/10.30605/2sv1r204Keywords:
Papaya peel extract, anti-acne serum, Staphylococcus epidermidis, Cutibacterium acnesAbstract
Staphylococcus epidermidis and Cutibacterium acnes are two bacteria that cause acne. Papaya peel extract (Carica papaya L.) is used to make anti-acne serum, which contains flavonoid compounds that can stop bacterial growth. The purpose of this study is to find out how well papaya peel extract (Carica papaya L.) inhibits the growth of Cutibacterium acnes and Staphylococcus epidermidis bacteria. The antibacterial activity test was carried out using the disk diffusion technique with doses of 10%, 15%, 20%, and 25%. The results showed inhibition zone sizes of 16.1 mm, 18.8 mm, 21.4 mm, and 23.8 mm for Staphylococcus epidermidis . In addition, the inhibition zone sizes for Cutibacterium acnes were 15.1 mm, 16.3 mm, 17.8 mm, and 19.8 mm. The inhibition test results of the serum were 14.8 mm at a 10% concentration and 16.6 mm at a 15% concentration for S. epidermidis bacteria, and 12.2 mm at a 10% concentration and 13.2 mm at a 15% concentration for C. acnes bacteria. Analysis of Variance (ANOVA) with a significance value of p<0.05 was used to analyze these test results. This study shows the antibacterial effectiveness of acne serum made from papaya skin extract (Carica papaya L.) against Cutibacterium acnes and Staphylococcus epidermidis . The effective concentrations were 10% and 15%. In addition, the serum formulation met good requirements for homogeneity, stable viscosity, appropriate pH, and pleasant organoleptic quality.
References
Aprilia, F., & Mayasari, U. (2025). Papaya Seed Essential Oil Anti-Acne Cream and Its Effectiveness Against Staphylococcus epidermidis and Cutibacterium acnes. Biology, Medicine, & Natural Product Chemistry, 14(2), 1607-1616.
Deswita Wiwid, Efrida Pima sari Tambuna & Kartika Manalu, 2021. Uji efektifitas Antibakteri Ekstrak Umbi Lobak Putih (Raphanus sativus L.) Terhadap 54 Pertumbuhan Bakteri Propionibacterium acnes dan Staphylococus epidermidis. Jurnal Klorofil. Vol 5. No.2.
Fadhillah R,. F,. Pitono dabn Fitriah, G. 2024. Uji Daya Hambat Pertumbuhan Bakteria Escherichia coli Menggunakan ekstrak Rimpang Kunyit Curcuma Dosmetica Val. Jurnal Kesehatan Rajawali. 9(2).
Hanif Muhammad, Fathur R, 2024. Uji Aktivitas Antivakteri Sediaan Serum Anti Jerawat Ekstrak Daun Kersen (Muntingia calabura) Terhadap Bakteri Staphylococcus aureus ATCC 25923. Jurnal Farmasi Indonesia. Vol 5. No 3.
Hidayati, N,. Budiman dan Sarmini 2024. Formulasi Sediaan Serum Eksrak Etanol Umbi Hati Tanah. Jurnal farmasetis.12(2).
Isnaeni Dewi, Eka Nurhunaida. 2019. Uji Efektivitas Antibakteri Ekstrak Kulit 55 Buah Pepaya (Carica Papaya L.) Terhadap Propioni bacterium acnes. Majalah Farmasi Nasional.
Liandhajani, Antonius Padua Ratu & Neng Fitria, 2022. Karakteristik Dan Stabilitas Sediaan Serum Ekstrak Buah Kersen (Muntingia callabura L.) Dengan variasi Konsnetrasi. Jurnal Farmamedika. Vol 7. No.1.
Maharani Tri Anita, Norhabibah, (2024). Pengembangan Formulasi Clay Mask Stick Eklstrak Rumput Gandum (Triticum aestivum L.) Komoditas Lokal yang Berpotensi Sebagai Antioksidan. Jurnal Surya Medika.
Nurhaini Siti, Siti Aisyah & Turahman Taufik, 2023. Formulasi Slepping Mask Ekstrak Daun Teh Hijau (Camellia sinensis L.) dengan Variasi Konsnetrasi karpobol 940 dan Uji Aktivitas Antibakteri Terhadap Propionibacterium acnes. Jurnal Farmasi Islam.
Pribadhi A.N,. Sri, M., dan Ellyaka, P. 2023. Aktivitas Antibakteri dari bakteri Probiotik Dalam Melawan Propionibacterium acnes dan Staphylococcus epidermidis. Jurnal Farmasi Indobiosains. 5(1).
Purwandhini, D. D. R., Asri, M. T., & Yakub, P. (2024). Aktivitas Antibakteri Ekstrak Buah Pepaya Muda (Carica papaya L.) terhadap Bakteri Propionibacterium acnes Penyebab Jerawat. LenteraBio: Berkala Ilmiah Biologi, 13(3), 342-348.
Raysha Mc Seer, Rini Dwiastuti, Eka Indra Setyawan, 2021. Formulasi dan Uji Efektivitas Serum Anti Jerawat Ekstrak Etanol 96% Kacang Mete Daun (Anacardium occidentale L.). Jurnal Ilmiah Dermatologi dan Venereologi.
Rahman, D T., Sutrisna, E. M., dan Candrasari, 2012. Uji Efek Antibakteri Elstrak Etil Asetat Dan Klorofom Meniran (Phyllanthus Niruri Linn) Terhadap Pertumbuhan Bakteri Staphylococus Aureus Atcc 6538 Dan Escherichia Coli Atcc 11229 Secara In Vitro. Biomedia, 4(2).
Sari Kartika, Shelly Tauhersia & Indrawati Teti, (2020). Pengembangan Krim Antioksidan Ekstrak Kulit Buah Pepaya (Carica papaya L.) Dan Ekstrak Kulit Buah Rambutan (Nephelium lappaceum L.) EXOCARPS. Jurnal Farmasi Indonesia.
Sari, R. a., dan Pratiwi, R. 2020. Pengaruh Pelarut Terhadap aktivitas Antibakteri Ekstrak Tumbuhan Obat. Jurnal Biologi Tropis. 10(1).
Saptowo Ari, Risa Supriningrum. 2022. Uji Aktivitas Antibakteri Ekstrak Kulit Batang Sekilang (Embeliaborneensis Scheff) Terhadap Bakteri Propionibacterium acnes dan Staphylococcus epidermidis. Jurnal Al Ulum Sains dan Teknologi. Vol.7. No. 2.
Setiawan Alissa Putri, Destira sari Indah & Rahmawanty Dina, 2023. Formulasi dan Evaluasi Sifat Fisik Sediaan serum Wajah ekstrak Daun singkong (Manihot esculenta) dengan Variasi Konsentrasi
Winato Mahardika Brigad, Efan Sanjaya, & Lisdawaty Siregar. 2019. Uji Efektivitas Antibakteri Ekstrak Daun Serai Wangi (Cymbopogen nardus) Terhadap Bakteri Propionibacterium acnes. Jurnal BioLink. 6(1).
Zahra Nova, Panji Wahlanto. 2023. Uji Iritasi Dermal Sediaan Salep Kulit Dari Getah Buah Pepaya California (Carica papaya L.) Pada Hewan Uji Kelinci. Jurnal Pharmacy Genius. 2(2).
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